Due to the challenges of dependancy, abuse, and misuse with opioids, even at suggested doses [see Warnings and Precautions (five.1)], reserve Promethazine HCl and Codeine Phosphate Oral Resolution for use in Grownup individuals for whom the many benefits of cough suppression are predicted to outweigh the pitfalls, As well as in whom an ample assessment in the etiology in the cough has actually been created.
Use an exact measuring machine to evaluate your dose of promethazine/codeine. A residence spoon is not really an correct measuring unit and will result in you to choose the wrong dose. Question your pharmacist to advocate an acceptable measuring system.
The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complex, necessitating cautious consideration of the consequences to the mother or father drug, codeine, as well as the Lively metabolite, morphine.
It truly is soluble in drinking water and freely soluble in Alcoholic beverages. The molecular fat is 320.88. Its molecular formulation is C17H20N2S•HCl, and it's the following chemical composition.
The concomitant use of Promethazine HCl and Codeine Phosphate Oral Remedy with all cytochrome P450 3A4 inducers or discontinuation of the cytochrome website P450 3A4 inhibitor may well result in reduced codeine amounts, greater norcodeine levels, and fewer metabolism by means of 2D6 with resultant decreased morphine ranges.
Promethazine is nicely absorbed from your gastrointestinal tract. Scientific outcomes are obvious within twenty minutes immediately after oral administration and usually previous four to 6 hrs, Even though They could persist as long as 12 hrs.
Like other codeine products and solutions, codeine linctus is usually routine-forming and may lead to addiction or overdose.
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A pharmacist can propose an proper measuring unit and can provide Directions for measuring the right dose.
Chance of Misuse and Addiction. Misusing promethazine/codeine may lead to critical Unwanted effects like coma or death. Misuse suggests having a drugs in a means other than how it absolutely was prescribed.
Administration of codeine may very well be accompanied by histamine launch and should be made use of with warning in atopic small children.
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Codeine has fantastic antitussive exercise, While less than that of morphine at equivalent doses. It can be Utilized in choice to morphine, read more simply because Negative effects are infrequent at the same old antitussive dose of codeine.
No proof of tumorigenicity was observed in male and woman mice at codeine dietary doses here as many as 400 mg/kg/working day (somewhere around akin to 45 times the MRHD over a mg/m2 basis).